Abramovitch$507877$ - traducción al holandés
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Abramovitch$507877$ - traducción al holandés

CHEMICAL COMPOUND
Triptamine; Abramovitch-Shapiro tryptamine synthesis; Tryptamide
  • Conversion of tryptophan to tryptamine, followed by its degradation to indole-3-acetic acid
  • Naratriptan
  • Rizatriptan
  • Sumatriptan
  • All tryptamine derivatives possess a modified 2-aminoethyl  group and/or the addition of a substituent on the indole.
  • Zolmitriptan

Abramovitch      
n. familienaam

Wikipedia

Tryptamine

Tryptamine is an indolamine metabolite of the essential amino acid, tryptophan. The chemical structure is defined by an indole—a fused benzene and pyrrole ring, and a 2-aminoethyl group at the second carbon (third aromatic atom, with the first one being the heterocyclic nitrogen). The structure of tryptamine is a shared feature of certain aminergic neuromodulators including melatonin, serotonin, bufotenin and psychedelic derivatives such as dimethyltryptamine (DMT), psilocybin, psilocin and others. Tryptamine has been shown to activate trace amine-associated receptors expressed in the mammalian brain, and regulates the activity of dopaminergic, serotonergic and glutamatergic systems. In the human gut, symbiotic bacteria convert dietary tryptophan to tryptamine, which activates 5-HT4 receptors and regulates gastrointestinal motility. Multiple tryptamine-derived drugs have been developed to treat migraines, while trace amine-associated receptors are being explored as a potential treatment target for neuropsychiatric disorders.

For a list of tryptamine derivatives, see: List of substituted tryptamines.